The Official Statement on cheating in Call of Duty Blackops 2 cheating. Love it! -Source
What anti-cheat will be used?
Anti-cheat is a top priority for Call of Duty®: Black Ops II. We have developed our own proprietary server-side anti-cheat technology which will work alongside VAC to deliver the most advanced detection and banning capabilities of any Call of Duty game to date. We have also improved our player reporting system to make it the most effective way that you can help us catch cheaters. And starting on launch day we will have a full-time dedicated pc anti-cheat team focused solely on detecting and banning cheaters. We have a zero tolerance policy on cheating. Cheaters bans are permanent.